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Test Code VENLA Venlafaxine, Serum

Specimen Required

Collection Container/Tube: Red top (serum gel/SST are not acceptable)

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions:

1. Draw blood immediately before next scheduled dose.

2. Blood drawn from patients 12 hours after an oral dose is also appropriate. It is customary to treat the patient at bedtime with a dose, and then collect specimen the following morning prior to next dose.

3. Centrifuge and aliquot serum into a plastic vial within 2 hours of collection.

Useful For

Monitoring serum concentration during therapy


Evaluating potential toxicity


Evaluating patient compliance

Method Name

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Reporting Name

Venlafaxine, S

Specimen Type

Serum Red

Specimen Minimum Volume

0.4 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Red Refrigerated (preferred) 28 days
  Ambient  28 days
  Frozen  28 days

Reject Due To

Gross hemolysis OK
Gross lipemia OK
Gross icterus OK

Reference Values

Venlafaxine + O-desmethylvenlafaxine: 100-400 ng/mL

Day(s) Performed


Report Available

1 to 4 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed, and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
VENLA Venlafaxine, S 62849-5


Result ID Test Result Name Result LOINC Value
83732 Venlafaxine 9630-5
30195 O-desmethyl Venlafaxine 9630-5
32182 Venlafaxine+O-Desmethylvenlafaxine 62849-5


If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.