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Test Code UPGD Uroporphyrinogen Decarboxylase (UPG D), Whole Blood


Advisory Information


Porphyria cutanea tarda (PCT) type I, the most common form of PCT, exhibits normal RBC enzyme activity. The preferred test for diagnosis of type I is PQNU / Porphyrins, Quantitative, 24 Hour, Urine or PQNRU / Porphyrins, Quantitative, Random, Urine.



Necessary Information


Include a list of medications the patient is currently taking.



Specimen Required


All porphyrin tests on whole blood can be performed on 1 draw tube.

 

Patient Preparation: Patient should abstain from alcohol for 24 hours

Container/Tube:

Preferred: Green top (sodium heparin)

Acceptable: Lavender top (EDTA) or light, green top (lithium heparin)

Specimen Volume: Full tube

Collection Instructions: Immediately place specimen on wet ice.


Useful For

Preferred test for the confirmation of a diagnosis of porphyria cutanea tarda type II and hepatoerythropoietic porphyria

Testing Algorithm

The following algorithms are available in Special Instructions:

-Porphyria (Acute) Testing Algorithm

-Porphyria (Cutaneous) Testing Algorithm

Method Name

High-Performance Liquid Chromatography (HPLC)/Incubation of Lysed Erythrocytes

Reporting Name

UPG Decarboxylase, WB

Specimen Type

Whole blood

Specimen Minimum Volume

3 mL

Specimen Stability Information

Specimen Type Temperature Time
Whole blood Refrigerated 7 days

Reject Due To

Hemolysis

Mild reject; Gross reject

Lipemia

NA

Icterus

NA

Other

NA

Reference Values

>1.0 Relative Units (normal)

0.80-0.99 Relative Units (indeterminate)

<0.80 Relative Units (porphyria cutanea tarda or hepatoerythropoietic porphyria)

Day(s) and Time(s) Performed

Tuesday; 8 a.m.

Analytic Time

3 days (Not reported on Saturday or Sunday)

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

82657

LOINC Code Information

Test ID Test Order Name Order LOINC Value
UPGD UPG Decarboxylase, WB 49596-0

 

Result ID Test Result Name Result LOINC Value
8599 UPG Decarboxylase, WB 49596-0