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Test Code TAPEN Tapentadol and Metabolite, Random, Urine

Advisory Information

If submitting for multiple tests on 1 order, submit a total volume of 5 mL per test ordered in a single plastic container.

Specimen Required

Supplies: Aliquot Tube, 5 mL (T465)

Collection Container/Tube: Plastic urine container

Submission Container/Tube: Aliquot Tube, 5 mL (T465)

Specimen Volume: 2 mL

Collection Instructions: No preservative.

Useful For

Monitoring of compliance utilizing tapentadol


Detection and confirmation of the illicit use of tapentadol

Method Name

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Reporting Name

Tapentadol and Metabolite, U

Specimen Type


Specimen Minimum Volume

0.1 mL

Specimen Stability Information

Specimen Type Temperature Time
Urine Refrigerated (preferred) 14 days
  Ambient  14 days
  Frozen  14 days

Reject Due To









Reference Values

Cutoff: 25 ng/mL


Note: Tapentadol concentrations will be reported quantitatively and N-desmethyltapentadol will be reported qualitatively (Present or Negative).

Day(s) and Time(s) Performed

Monday, Wednesday, Friday; 2nd Shift

Analytic Time

2 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information


G0480 (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
TAPEN Tapentadol and Metabolite, U In Process


Result ID Test Result Name Result LOINC Value
35916 Tapentadol 65807-0
35917 N-desmethyltapentadol 65808-8