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Test Code PROI Prothrombin Time (PT), Plasma

Methodology

Mechanical Clot Detection

Specimen Requirements

1. Draw blood in a blue-top (citrate) tube(s). Send specimen to laboratory within 8 hours at ambient temperature.
2. If specimen is to be stored longer than 8 hours spin down, remove plasma, spin plasma again, and place 1 mL of citrate platelet-poor plasma in plastic vial. (Glass vial is not acceptable.)

Note:  Double-centrifuged specimen is critical for accurate results as platelet contamination may cause spurious results.
3. Freeze specimen immediately at ≤-40° C, if possible.
4. Send specimen frozen.
Note:  1. Each coagulation assay requested should have its own vial.
2. If the patient is being treated with Coumadin®, this should be noted. Coumadin® will lower protein C.
3. Heparin >2 U/mL may interfere with this assay.
4. Lipemic specimen may be rejected.

Specimen Stability Information

 

Specimen Type

Temperature

Time

Platelet-poor plasma, citrated

RT, spun

8 hrs

 

Reference Values

PROTHROMBIN TIME  (PT)  :  12.5 - 15.5 seconds

INTERNATIONAL NORMALIZED RATIO (INR) :  0.9 - 1.2 (non-anticoagulated)
Critical value:  INR >4.5 


Recommended INR values for therapeutic anticoagulant treatment of the stated conditions.

 

INR:  2.0-3.0
Prophylaxis of venous thrombosis (high-risk surgery) Treatment of DVT and PE
Prevention of embolism:
Tissue heart valves
Acute MI
Valvular heart disease
Atrial fibrillation
Bileaflet mechanical valve in aortic position

 

INR: 2.5-3.5
Recurrent MI
Mechanical prosthetic valves (high-risk)

Reject Due To

Hemolysis

Mild:

ok

Gross:

ok

Lipemia

Mild:

ok

Gross:

ok

Icterus

Mild:

ok

Gross:

ok

 

Day(s) Test Set Up

Monday through Sunday

CPT Coding

85610

Secondary ID

HHA229

Performing Laboratory

Huntsville Hospital Laboratory/Madison Hospital Laboratory