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Test Code PBNP pro-BNP, Plasma or Serum

Methodology

Chemiluminescence

Specimen Requirements

Submit only 1 of the following specimens:

 

Plasma

Draw blood in a green-top (lithium heparin) tube(s). Spin down and send 1 mL of lithium heparin plasma refrigerated.

Note:  Label specimen appropriately (plasma).

 

Serum

Draw blood in a plain, red-top tube(s) or a serum gel tube(s). Spin down and send 1 mL of serum refrigerated.

Note:  Label specimen appropriately (serum).

Specimen Stability Information

 

Specimen Type

Temperature

Time

Plasma,lithium heparin / Serum

RT, spun

 3 days
 

Refrigerated, spun

 6 days

 

Reference Values

 

Age

Male (pg/mL)

Female (pg/mL)

< 45 years

< 93

< 178

45 – 54 years

< 138

< 192

55 – 64 years

< 177

< 226

65 – 74 years

< 229

< 353

> 74 years

< 450

< 450

Notes:

- Interpretation for under 50 years of age:

N-terminal pro brain natriuretic peptide (NT-proBNP) values below 300 pg/mL have 99% negative predictive value for excluding acute congestive heart failure (CHF). A cutoff of 1,200 pg/mL for patients with an estimated glomerular filtration rate (eGFR) below 60 yields a diagnostic sensitivity and specificity of 89% and 72% for acute CHF. NT-proBNP values greater than 450 pg/mL are consistent with CHF in adults under 50 years of age.

 

-Interpretation for 50 - 75 years of age:

 N-terminal pro brain natriuretic peptide (NT-proBNP) values below 300 pg/mL have 99% negative predictive value for excluding acute congestive heart failure (CHF). A cutoff of 1,200 pg/mL for patients with an estimated glomerular filtration rate (eGFR) below 60 yields a diagnostic sensitivity and specificity of 89% and 72% for acute CHF. A diagnostic NT-proBNP cutoff of 900 pg/mL has been suggested in adults 50 to 75 years of age in the absence of renal failure.

 

-Interpretation for over 75 years of age:

N-terminal pro brain natriuretic peptide (NT-proBNP) values below 300 pg/mL have 99% negative predictive value for excluding acute congestive heart failure (CHF). A cutoff of 1,200 pg/mL for patients with an estimated glomerular filtration rate (eGFR) below 60 yields a diagnostic sensitivity and specificity of 89% and 72% for acute CHF. A diagnostic NT-proBNP cutoff of 1,800 pg/mL has been suggested in adults over 75 years of age in the absence of renal failure.

 

Reject Due To

 

Hemolysis

Mild:

ok

Gross:

ok

Lipemia

Mild:

ok

Gross:

ok

Icterus

Mild:

ok

Gross:

ok

 

Day(s) Test Set Up

Monday through Sunday

CPT Coding

83880

Secondary ID

HHA1465

Performing Laboratory

Huntsville Hospital Laboratory/Madison Hospital Laboratory

LOINC Coding

Test Name LOINC Code

pro-BNP, Plasma or Serum

 33762-6
Comment 8251-1