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Test Code PBNP pro-BNP, Plasma or Serum

Methodology

Chemiluminescence

Specimen Requirements

Submit only 1 of the following specimens:

 

Plasma

Draw blood in a green-top (lithium heparin) tube(s). Spin down and send 1 mL of lithium heparin plasma refrigerated.

Note:  Label specimen appropriately (plasma).

 

Serum

Draw blood in a plain, red-top tube(s) or a serum gel tube(s). Spin down and send 1 mL of serum refrigerated.

Note:  Label specimen appropriately (serum).

Reject Due To

 

Hemolysis

Mild:

ok

Gross:

ok

Lipemia

Mild:

ok

Gross:

ok

Icterus

Mild:

ok

Gross:

ok

 

Reference Values

 

Age

Male (pg/mL)

Female (pg/mL)

< 45 years

< 93

< 178

45 – 54 years

< 138

< 192

55 – 64 years

< 177

< 226

65 – 74 years

< 229

< 353

> 74 years

< 450

< 450

Notes:

- Interpretation for under 50 years of age:

N-terminal pro brain natriuretic peptide (NT-proBNP) values below 300 pg/mL have 99% negative predictive value for excluding acute congestive heart failure (CHF). A cutoff of 1,200 pg/mL for patients with an estimated glomerular filtration rate (eGFR) below 60 yields a diagnostic sensitivity and specificity of 89% and 72% for acute CHF. NT-proBNP values greater than 450 pg/mL are consistent with CHF in adults under 50 years of age.

 

-Interpretation for 50 - 75 years of age:

 N-terminal pro brain natriuretic peptide (NT-proBNP) values below 300 pg/mL have 99% negative predictive value for excluding acute congestive heart failure (CHF). A cutoff of 1,200 pg/mL for patients with an estimated glomerular filtration rate (eGFR) below 60 yields a diagnostic sensitivity and specificity of 89% and 72% for acute CHF. A diagnostic NT-proBNP cutoff of 900 pg/mL has been suggested in adults 50 to 75 years of age in the absence of renal failure.

 

-Interpretation for over 75 years of age:

N-terminal pro brain natriuretic peptide (NT-proBNP) values below 300 pg/mL have 99% negative predictive value for excluding acute congestive heart failure (CHF). A cutoff of 1,200 pg/mL for patients with an estimated glomerular filtration rate (eGFR) below 60 yields a diagnostic sensitivity and specificity of 89% and 72% for acute CHF. A diagnostic NT-proBNP cutoff of 1,800 pg/mL has been suggested in adults over 75 years of age in the absence of renal failure.

 

Day(s) Test Set Up

Monday through Sunday

CPT Coding

83880

Performing Laboratory

Huntsville Hospital Laboratory/Madison Hospital Laboratory

Secondary ID

HHA1465

LOINC Coding

Test Name LOINC Code

pro-BNP, Plasma or Serum

 33762-6
Comment 8251-1

 

Specimen Stability Information

 

Specimen Type

Temperature

Time

Plasma,lithium heparin / Serum

RT, spun

 3 days
 

Refrigerated, spun

 6 days