Reference Values

INSULIN-LIKE GROWTH FACTOR 1

Male:

<1 year: 27.0-157.0 ng/mL

1 year: 29.7-166.8 ng/mL

2 years: 33.9-183.9 ng/mL

3 years: 39.0-204.5 ng/mL

4 years: 44.3-225.0 ng/mL

5 years: 50.0-245.5 ng/mL

6 years: 56.2-267.1 ng/mL

7 years: 63.4-291.9  ng/mL

8 years: 72.4-323.1 ng/mL

9 years: 83.6-361.6 ng/mL

10 years: 96.9-406.6 ng/mL

11 years: 111.6-454.4 ng/mL

12 years: 126.1-498.7 ng/mL

13 years: 138.6-532.5 ng/mL

14 years: 147.5-551.2 ng/mL

15 years: 152.2-553.5 ng/mL

16 years: 152.9-541.8 ng/mL

17 years: 150.6-520.6 ng/mL

18 years: 146.2-493.6 ng/mL

19 years: 140.2-462.7 ng/mL

20 years: 133.1-430.0 ng/mL

21-25 years: 115.2-354.8 ng/mL

26-30 years: 97.9-281.6 ng/mL

31-35 years: 88.3- 246.0 ng/mL

36-40 years: 83.4-232.7 ng/mL

41-45 years: 74.9-216.4 ng/mL

46-50 years: 66.9-205.1 ng/mL

51-55 years: 60.6-200.3 ng/mL

56-60 years: 54.3-194.2 ng/mL

61-65 years: 48.8-187.7 ng/mL

66-70 years: 46.5-191.9 ng/mL

71-75 years: 40.9-179.2 ng/mL

76-80 years: 37.1-172.0 ng/mL

81-85 years: 33.8-165.4 ng/mL

86-90 years: 32.2-166.1 ng/mL

Females:

<1 year: 17.9-125.6 ng/mL

1 year: 19.5-132.3 ng/mL

2 years: 22.2-145.4 ng/mL

3 years: 25.9-164.2 ng/mL

4 years: 30.7-187.8 ng/mL

5 years: 36.2-214.4 ng/mL

6 years: 42.0-240.4 ng/mL

7 years: 48.6-269.6 ng/mL

8 years: 56.9-305.3 ng/mL

9 years: 67.2-349.4 ng/mL

10 years: 79.5-400.3 ng/mL

11 years: 92.6-452.6 ng/mL

12 years: 105.3- 499.1 ng/mL

13 years: 115.9-533.4 ng/mL

14 years: 123.4-552.0 ng/mL

15 years: 127.4-554.2 ng/mL

16 years: 127.9-541.5 ng/mL

17 years: 125.3-517.3 ng/mL

18 years: 120.5-485.8 ng/mL

19 years: 114.4-450.8 ng/mL

20 years: 107.8-416.0 ng/mL

21-25 years: 92.9-342.0 ng/mL

26-30 years: 78.4-270.0 ng/mL

31-35 years: 73.1-243.0 ng/mL

36-40 years: 69.0-227.0 ng/mL

41-45 years: 61.5-204.4 ng/mL

46-50 years: 56.8-194.5 ng/mL

51-55 years: 53.0-189.6 ng/mL

56-60 years: 45.6-172.4 ng/mL

61-65 years: 42.2-169.0 ng/mL

66-70 years: 38.3-162.5 ng/mL

71-75 years: 36.6-164.7 ng/mL

76-80 years: 34.7-164.8 ng/mL

81-85 years: 34.4-172.4 ng/mL

86-90 years: 33.6-177.8 ng/mL

Tanner stage reference intervals:

Males:

I : 81.3-255.3 ng/mL

II: 106.2-432.3 ng/mL

III: 244.9-511.4 ng/mL

IV: 222.6-577.7 ng/mL

V: 227.4-517.8 ng/mL

Females:

I: 85.9-323.0 ng/mL

II: 117.5-451.3 ng/mL

III: 258.3-528.5 ng/mL

IV: 224.2-585.8 ng/mL

V: 188.2-511.6 ng/mL

Tanner Stage reference source: Bindlingmaier M, Friedrich N, Emeny RT,et al. Reference intervals for insulin-like growth factor-1 (IGF-1) from birth to senescence: results from a multicenter study using a new automated chemiluminescence IGF-I immunoassay conforming to recent international recommendations. J Clin Endocrinol Metab. 2014;99(5):1712-1721

Note: Puberty onset (transition from Tanner stage I to Tanner stage II) occurs for boys at a median age of 11.5 (±2) years and for girls at a median age of 10.5 (±2) years. There is evidence that it may occur up to 1 year earlier in obese girls and in African American girls. For boys, there is no definite proven relationship between puberty onset and body weight or ethnic origin. Progression through Tanner stages is variable. Tanner stage V (young adult) should be reached by age 18.

INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3

1-7 days: ≤0.7 mcg/mL

8-14 days: 0.5-1.4 mcg/mL

15 days-11 months: Unavailable

1 year: 0.7-3.6 mcg/mL

2 years: 0.8-3.9 mcg/mL

3 years: 0.9-4.3 mcg/mL

4 years: 1.0-4.7 mcg/mL

5 years: 1.1-5.2 mcg/mL

6 years: 1.3-5.6 mcg/mL

7 years: 1.4-6.1 mcg/mL

8 years: 1.6-6.5 mcg/mL

9 years: 1.8-7.1 mcg/mL

10 years: 2.1-7.7 mcg/mL

11 years: 2.4-8.4 mcg/mL

12 years: 2.7-8.9 mcg/mL

13 years: 3.1-9.5 mcg/mL

14 years: 3.3-10 mcg/mL

15 years: 3.5-10 mcg/mL

16 years: 3.4-9.5 mcg/mL

17 years: 3.2-8.7 mcg/mL

18 years: 3.1-7.9 mcg/mL

19 years: 2.9-7.3 mcg/mL

20 years: 2.9-7.2 mcg/mL

21-25 years: 3.4-7.8 mcg/mL

26-30 years: 3.5-7.6 mcg/mL

31-35 years: 3.5-7.0 mcg/mL

36-40 years: 3.4-6.7 mcg/mL

41-45 years: 3.3-6.6 mcg/mL

46-50 years: 3.3-6.7 mcg/mL

51-55 years: 3.4-6.8 mcg/mL

56-60 years: 3.4-6.9 mcg/mL

61-65 years: 3.2-6.6 mcg/mL

66-70 years: 3.0-6.2 mcg/mL

71-75 years: 2.8-5.7 mcg/mL

76-80 years: 2.5-5.1 mcg/mL

81-85 years: 2.2-4.5 mcg/mL

Tanner Stages:

Males

Stage I: 1.4-5.2 mcg/mL

Stage II: 2.3-6.3 mcg/mL

Stage III: 3.1-8.9 mcg/mL

Stage IV: 3.7-8.7 mcg/mL

Stage V: 2.6-8.6 mcg/mL

Females

Stage I: 1.2-6.4 mcg/mL

Stage II: 2.8-6.9 mcg/mL

Stage III: 3.9-9.4 mcg/mL

Stage IV: 3.3-8.1 mcg/mL

Stage V: 2.7-9.1 mcg/mL

Note: Puberty onset (transition from Tanner stage I to Tanner stage II) occurs for boys at a median age of 11.5 (±2) years and for girls at a median age of 10.5 (±2) years. There is evidence that it may occur up to 1 year earlier in obese girls and in African American girls. By contrast, for boys there is no definite proven relationship between puberty onset and body weight or ethnic origin. Progression through Tanner stages is variable. Tanner stage V (young adult) should be reached by age 18.